Mark Derbyshire

Project Leader / Research Fellow

mark.derbyshire@curtin.edu.au

08 9266 2369

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Curtin Staff Profile

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Biography

Mark is originally from the UK where he obtained a PhD in molecular science from Bristol University. During his PhD he worked in collaboration with the agriscience company Syngenta on an important disease of wheat. In 2015, he emigrated to Australia to join the CCDM where his research has been focused on novel ways to improve the efficiency of canola breeding for disease resistance.

Mark has a broad knowledge of the molecular biology of plants and their pathogens. He is also a keen computational scientist and statistician, with expertise in statistical breeding, population genetics and bioinformatics. In his role as project leader at the CCDM, Mark brings together the diverse expertise of himself and his colleagues to work towards improving disease management in canola. He has a strong passion for plant breeding and enjoys seeing innovative techniques being put into practice.

Related Resources & Publications

Derbyshire M. C. and Raffaele S. (2023) "Till death do us pair: Co-evolution of plant–necrotroph interactions" Current Opinion in Plant Biology. DOI: https://doi.org/10.1016/j.pbi.2023.102457

Regmi, R., Newman, T.E., Khentry, Y., Kamphuis, L.G., Derbyshire, M.C. (2023). "Genome-wide identification of Sclerotinia sclerotiorum small RNAs and their endogenous targets" BMC Genomics. DOI: https://doi.org/10.1186/s12864-023-09686-7

Derbyshire, M.C., Raffaele, S., (2023). "Surface frustration re-patterning underlies the structural landscape and evolvability of fungal orphan candidate effectors" Nature Communications. DOI: https://doi.org/10.1038/s41467-023-40949-9

Jones D, Fornarelli R, Derbyshire M, Gibberd M, Barker K, Hane J. (2023). "The pursuit of genetic gain in agricultural crops through the application of machine-learning to genomic prediction" Front. Genet. DOI: https://doi.org/10.3389/fgene.2023.1186782

Derbyshire, M. C., Marsh, J., Tirnaz, S., Nguyen, H. T., Batley, J., Bayer, P. E., & Edwards, D. (2023). "Diversity of fatty acid biosynthesis genes across the soybean pangenome." The Plant Genome DOI: https://doi.org/10.1002/tpg2.20334

Newman, T. E., Kim, H., Khentry Y., Sohn, K. H., Derbyshire M. and Kamphuis L. G. (2023) "The broad host range pathogen Sclerotinia sclerotiorum produces multiple effector proteins that induce host cell death intracellularly." Molecular Plant Pathology. DOI: https://doi.org/10.1111/mpp.13333

Newman, T. E., Khentry Y., Leo A., Lindbeck K., Kamphuis L. G., and Derbyshire M. (2023) "Association mapping combined with whole genome sequencing data reveals candidate causal variants for sclerotinia stem rot resistance in Brassica napus." Phytopathology. DOI: https://doi.org/10.1094/PHYTO-06-22-0217-FI

Cao C.T.H., Derbyshire M.C., Regmi R., Li H., Jones M.G.K. and Wylie S.J. (2022) "Small RNA Analyses of a Ceratobasidium Isolate Infected with Three Endornaviruses" Viruses. DOI: https://doi.org/10.3390/v14102276

Derbyshire M.C., Batley J. and Edwards D. (2022) "Use of multiple ‘omics techniques to accelerate the breeding of abiotic stress tolerant crops" Current Plant Biology. DOI: https://doi.org/10.1016/j.cpb.2022.100262

Derbyshire, M.C., Newman, T.E., Khentry, Y., Taiwo, A. (2022) "The evolutionary and molecular features of the broad-host-range plant pathogen Sclerotinia sclerotiorum" Molecular Plant Pathology. DOI: doi.org/10.1111/mpp.13221

Mwape, V., Khoo, K.H.P., Chen, K., Khentry, Y., Newman, T.E., Derbyshire, M.C., Mather, D.E., Kamphuis, L.G. (2022) "Identification of Sclerotinia stem rot resistance quantitative trait loci in a chickpea (Cicer arietinum) recombinant inbred line population" Functional Plant Biology. DOI: https://doi.org/10.1071/FP21216

Taiwo, A., Harper, L., Derbyshire, M. (2021) "Impacts of fludioxonil resistance on global gene expression in the necrotrophic fungal plant pathogen Sclerotinia sclerotiorum." BMC Genomics DOI: https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07402-x

Derbyshire, M.C., Harper, L.A., Lopez-Ruiz, F.J. (2021) "Positive Selection of Transcription Factors Is a Prominent Feature of the Evolution of a Plant Pathogenic Genus Originating in the Miocene" Genome Biology and Evolution. DOI: https://doi.org/10.1093/gbe/evab167

Derbyshire, M., Khentry, Y., Severn-Ellis, A., Mwape, V., Mohd Saad, NS., Newman, T., Taiwo, A., Regmi, R., Buchwaldt, L., Denton-Giles, M., Batley, J., Kamphius, L. (2021) "Modeling first order additive × additive epistasis improves accuracy of genomic prediction for sclerotinia stem rot resistance in canola." The Plant Genome. DOI: https://acsess.onlinelibrary.wiley.com/doi/10.1002/tpg2.20088

Regmi, R., Newman, T.E., Kamphuis, L.G., Derbyshire, M.C. (2021) "Identification of Brassica napus small RNAs responsive to infection by a necrotrophic pathogen" BMC Plant Biology. DOI: https://doi.org/10.1186/s12870-021-03148-6

Mwape, V.W., Mobegi, F.M., Regmi, R., Newman, T.E., Kamphuis, L.G., Derbyshire, M.C. (2021) "Analysis of differentially expressed Sclerotinia sclerotiorum genes during the interaction with moderately resistant and highly susceptible chickpea lines" BMC Genomics. DOI: https://doi.org/10.1186/s12864-021-07655-6

Mwape, V., Khentry, Y., Newman, T., Denton-Giles, M., Derbyshire, M., Chen, K., Berger, J., Kamphuis, L. (2021). "Identification of sources of Sclerotinia sclerotiorum resistance in a collection of wild Cicer germplasm." Plant Disease. DOI: https://doi.org/10.1094/PDIS-02-21-0367-RE

Graham-Taylor, C., Kamphuis, L.G., Derbyshire, M.C. (2020) "A detailed in silico analysis of secondary metabolite biosynthesis clusters in the genome of the broad host range plant pathogenic fungus Sclerotinia sclerotiorum." BMC Genomics DOI: https://doi.org/10.1186/s12864-019-6424-4

Derbyshire, M.C., (2020) "Bioinformatic Detection of Positive Selection Pressure in Plant Pathogens: The Neutral Theory of Molecular Sequence Evolution in Action." Frontiers in Microbiology. DOI: https://doi.org/10.3389/fmicb.2020.00644

Newman, T.E, Derbyshire, M.C. (2020) "The Evolutionary and Molecular Features of Broad Host-Range Necrotrophy in Plant Pathogenic Fungi" Frontiers in plant science DOI: https://doi.org/10.3389/fpls.2020.591733

Derbyshire, M., Mbengue, M., Barascud, M., Navaud, O., Raffaele, S. (2019) "Small RNAs from the plant pathogenic fungus Sclerotinia sclerotiorum highlight host candidate genes associated with quantitative disease resistance." Molecular Plant Pathology DOI: https://doi.org/10.1111/mpp.12841

Derbyshire, M.C., Denton-Giles, M., Hane, J.K., Chang, S., Mousavi-Derazmmahelleh, M., Raffaele, S., Buchwaldt, L., Kamphuis, L.G. (2019) "A whole genome scan of SNP data suggests a lack of abundant hard selective sweeps in the genome of the broad host range plant pathogenic fungus Sclerotinia sclerotiorum" PLOS One DOI: https://doi.org/10.1371/journal.pone.0214201

Lane, D., Denton-Giles, M., Derbyshire, M., and Kamphuis, L.G. (2019) "Abiotic conditions governing the myceliogenic germination of Sclerotinia sclerotiorum allowing the basal infection of Brassica napus" Australasian Plant Pathology DOI: https://doi.org/10.1007/s13313-019-0613-0

Allan, J., Regm"i, R., Denton-Giles, M., Kamphuis, L.G., Derbyshire, M.C. (2019). "The host generalist phytopathogenic fungus Sclerotinia sclerotiorum deferentially expresses multiple metabolic enzymes on two different plant hosts." Scientific Reports, nature.com. DOI: https://doi.org/10.1038/s41598-019-56396-w

Mousavi-Derazmahalleh, M., Chang, S., Thomas, G., Derbyshire, M., Bayer, P.E., Edwards, D., Nelson, M.N., Erskine, W., Lopez-Ruiz, F.J., Clements, J., and Hane, J.K. (2019) "Prediction of pathogenicity genes involved in adaptation to a lupin host in the fungal pathogens Botrytis cinerea and Sclerotinia sclerotiorum via comparative genomics" BMC Genomics DOI: https://doi.org/10.1186/s12864-019-5774-2

Denton-Giles, M., Derbyshire, M., Khentry, Y., Buchwaldt, L., Kamphuis, L.G. (2018) "Partial stem resistance in Brassica napus to highly aggressive and genetically diverse Sclerotinia sclerotiorum isolates from Australia" Canadian Journal of Plant Pathology Vol 40, 20`18 Issue 4 DOI: https://www.tandfonline.com/doi/full/10.1080/07060661.2018.1516699

Derbyshire, M., Gohari, A.M., Mehrabi, R., Kilaru,S., Steinberg, G., Ali, S., Bailey, A., Hammind-Kosack, K., Kema, G.H.J., Rudd, J.J. (2018) "Phosphopantetheinyl transferase (Ppt)-mediated biosynthesis of lysine, but not siderophores or DHN melanin, is required for virulence of Zymoseptoria tritici on wheat" Scientific reports 8, Art 17069 DOI: https://www.nature.com/articles/s41598-018-35223-8

Derbyshire MC, Mbengue M, Barascud M, Navaud O, Raffaele S (2018) "Small RNAs from the plant pathogenic fungus Sclerotinia sclerotiorum highlight candidate host target genes associated with quantitative disease resistance." bioRxiv DOI: https://doi.org/10.1101/354076

Lane, D.W., Kamphuis, L.G., Derbyshire, M.C., Denton-Giles, M. (2018) "Heat-dried sclerotia of Sclerotinia sclerotiorum myceliogenically germinate in water and are able to infect Brassica napus" Crop & Pasture Science DOI: https://doi.org/10.1071/CP18109

Derbyshire, M., Denton-Giles, M., Hegedus, D., Seifbarghy, S., Rollins, J., van Kan, J., Seidl, M.F., Faino, L., Mbengue, M., Navaud, O., Raffaele, S., Hammond-Kosack, K., Heard, S., Oliver, R.P. (2017) "The complete genome sequence of the phytopathogenic fungus Sclerotinia sclerotiorum reveals insights into the genome architecture of broad host range pathogens." Genome Biology and Evolution. DOI: https://doi.org/10.1093/gbe/evx030

Badet, T., Peyraud, R., Mbengue, M., Navaud, O., Derbyshire, M., Oliver, R.P., Barbacci, A., Raffaele, S. (2017) "Codon optimization underpins generalist parasitism in fungi." eLife. DOI: https://doi.org/10.7554/eLife.22472.001

Derbyshire, M.C., Denton-Giles, M. (2016) "The control of sclerotinia stem rot on oilseed rape (Brassica napus): current practices and future opportunities" Plant Pathology DOI: doi.org/10.1111/ppa.12517

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