Josh Mylne

Deputy Director

josh.mylne@curtin.edu.au

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Biography

Since earning his PhD in Botany at UQ in 2002, Josh has worked on plants from many angles and in several places. These include flowering time and vernalization (John Innes Centre 2001-2005), peptide biosynthesis (IMB UQ 2006-2012) and then, after founding a lab at Perth’s UWA in 2013, structural enzymology and herbicides.

He is a former ARC QEII and Future Fellow and Fulbright Scholar. In 2021 he took up the role of Deputy Director for the CCDM where he will pursue research into agrochemicals. His lab has a strong focus on the use of model plants, protein crystallography and chemical biology.

Related Resources & Publications

Haywood, J., Breese, K. J., Zhang, J., Waters, M. T., Bond, C. S., Stubbs, K. A., & Mylne, J. S. (2022). "A fungal tolerance trait and selective inhibitors proffer HMG-CoA reductase as a herbicide mode-of-action" Nature Communications. DOI: https://doi.org/10.1038/s41467-022-33185-0

Pires, D. E. V., Stubbs, K. A., Mylne, J. S., & Ascher, D. B. (2022). "cropCSM: designing safe and potent herbicides with graph-based signatures" Briefings in Bioinformatics. DOI: https://doi.org/10.1093/bib/bbac042

Sukhoverkov, K. V., Breese, K. J., Debowski, A. W., Murcha, M. W., Stubbs, K. A., & Mylne, J. S. (2022). "Inhibition of chloroplast translation as a new target for herbicides" RSC Chemical Biology. DOI: https://doi.org/10.1039/D1CB00192B

Vadlamani G., Sukhoverkov K.V., Haywood J., Breese K.J., Fisher M.F., Stubbs K.A., Bond C.S. and Mylne J.S. (2022) "Crystal structure of Arabidopsis thaliana HPPK/DHPS, a bifunctional enzyme and target of the herbicide asulam" Plant Communications. DOI: https://doi.org/10.1016/j.xplc.2022.100322

Payne, C.D., Vadlamani, G., Hajiaghaalipour, F., Muhammad, T., Fisher, M.F., Andersson, H.S., Göransson, U., Clark, R.J., Bond, C.S., Mylne, J.S., Rosengren, K.J. (2021) "Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides" RSC Chemical Biology. DOI: https://doi.org/10.1039/D1CB00155H

Payne, C.D., Fisher, M.F., Mylne, J.S., Rosengren, K.J. (2021) "Structural characterization of the PawL-Derived Peptide family, an ancient subfamily of orbitides" Journal of Natural Products. DOI: DOI: 10.1021/acs.jnatprod.1c00672

Sukhoverkov, K.V., Breese, K.J., Debowski, A.W., Murcha, M.W., Stubbs, K.A., Mylne, J.S. (2021) "Inhibition of chloroplast translation as a new target for herbicides" RSC Chemical Biology. DOI: https://doi.org/10.1039/D1CB00192B

Wallace, M.D., Debowski, A.W., Sukhoverkov, K.V., Mylne, J.S., Stubbs, K.A. (2021) "Herbicidal activity of fluoroquinolone derivatives" Plant Direct. DOI: https://doi.org/10.1002/pld3.348

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